Translational Neurophysiology & Brain Stimulation
MISSION
Dr. Luka Milosevic’s Translational Neurophysiology and Brain Stimulation (TNBS) research laboratory is committed to understanding brain function and dysfunction, and to the development of new methods to restore neurocircuit function and improve the lives of those with neurological disease.
TNBS operates in state-of-the-art wet and dry lab spaces at the Krembil Brain Institute. The team consists of students enrolled in graduate programs at University of Toronto, Postdoctoral Fellows, and Research personnel directly appointed at the University Health Network. We proudly collaborate with a multidisciplinary team of neurosurgeons, engineers, scientists, and other subject matter experts.
Projects at TNBS address the complete translational continuum from bench-to-bedside. We collect intracranial and cortical data during deep brain stimulation implantation surgeries for Parkinson’s and other neurological disorders. We leverage this data to uncover the disease pathology and the mechanisms of treatment. These studies co-occur with preclinical interrogations of the broader neural circuits using optogenetics and electrical stimulation in disease models, and computational modelling to evaluate the biophysical underpinnings of the treatment. Advancements are used to develop new methods of detecting pathological states and delivering therapeutic neuromodulation.
Prospective students and researchers with relevant experience can contact Dr. Milosevic by email at any time.
