Translational Neurophysiology & Brain Stimulation

Welcome!

The Toronto Western Hospital is a pioneering center for a neurosurgical procedure called deep brain stimulation (DBS). DBS is a standard of care procedure for patients with Parkinson's disease, essential tremor, dystonia, and has garnered much attention for many other refractory neurological disorders. The Toronto Western Hospital is also home of the Krembil Brain Institute and Dr. Luka Milosevic’s Translational Neurophysiology and Brain Stimulation (TNBS) research laboratory. The TNBS team is committed to understanding brain function and dysfunction, and to the development of new brain stimulation methods to improve the lives of those with neurological disease.

About Us

The TNBS lab leverages biomedical signal processing, machine learning, and computational modelling techniques in the context of in vivo brain research. The main interests of the lab include neurophysiological mechanisms of deep brain stimulation, synaptic plasticity, and pathophysiological processes in Parkinson’s disease and other neurological disorders. The lab works with human brain recording modalities across a range of spatial and temporal resolutions (ex. single-neuron recordings, local field potentials, ECoG, MEG), and state of the art preclinical techniques including optogenetics, fiber photometry, and high-density electrophysiology.